ParkinsonFranceV1, Main, Exploration, bibRecord, 000800

p62 Plays a Protective Role in the Autophagic Degradation of Polyglutamine Protein Oligomers in Polyglutamine Disease Model Flies*

Identifieur interne : 000800 ( Main/Exploration ); précédent : 000799; suivant : 000801

p62 Plays a Protective Role in the Autophagic Degradation of Polyglutamine Protein Oligomers in Polyglutamine Disease Model Flies*

Auteurs : Yuji Saitoh ; Nobuhiro Fujikake ; Yuma Okamoto ; H. Akiko Popiel ; Yusuke Hatanaka ; Morio Ueyama ; Mari Suzuki ; Sébastien Gaumer ; Miho Murata ; Keiji Wada ; Yoshitaka Nagai [Japon]

Source :

The Journal of Biological Chemistry [ 0021-9258 ] ; 2014.

RBID : PMC:4340391

Abstract

Background: Oligomers of pathogenic proteins are implicated in the pathomechanisms of neurodegenerative diseases.

Results: Depletion of p62 delays the degradation of polyglutamine protein oligomers via autophagy and exacerbates neurodegeneration in polyglutamine disease model flies.

Conclusion: p62 plays a protective role via autophagic degradation of polyglutamine protein oligomers.

Significance: p62 should be a therapeutic target for the polyglutamine diseases.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340391

DOI: 10.1074/jbc.M114.590281
PubMed: 25480790
PubMed Central: 4340391

Affiliations:

Japon

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
 Oligomers of pathogenic proteins are implicated in the pathomechanisms of neurodegenerative diseases.</p>
<p><bold>Results:</bold>
 Depletion of p62 delays the degradation of polyglutamine protein oligomers via autophagy and exacerbates neurodegeneration in polyglutamine disease model flies.</p>
<p><bold>Conclusion:</bold>
 p62 plays a protective role via autophagic degradation of polyglutamine protein oligomers.</p>
<p><bold>Significance:</bold>
 p62 should be a therapeutic target for the polyglutamine diseases.</p>
</div>
</front>
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<name sortKey="Gaumer, Sebastien" sort="Gaumer, Sebastien" uniqKey="Gaumer S" first="Sébastien" last="Gaumer">Sébastien Gaumer</name>
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La maladie de Parkinson en France (serveur d'exploration)

p62 Plays a Protective Role in the Autophagic Degradation of Polyglutamine Protein Oligomers in Polyglutamine Disease Model Flies*

p62 Plays a Protective Role in the Autophagic Degradation of Polyglutamine Protein Oligomers in Polyglutamine Disease Model Flies*

Source :

Abstract

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